Analysis of integrated optofluidic lab-on-a-chip fluorescence biosensor based on transmittance of light through a fluidic gap

Author

Krishnaswamy, Narayan ; Srinivas, T. ; Rao, G.Mohan

Author_Institution

Department of Instrumentation and Applied Physics, Indian Institute of Science, Bangalore 560012, India

fYear

2011

fDate

Aug. 30 2011-Sept. 3 2011

Firstpage

30

Lastpage

34

Abstract

Sensitivity analysis is an important aspect to be looked into while designing lab-on-a-chip systems. In this paper we will be showing with appropriate design that the best sensitivity of the fluorescence biosensor is achieved for an optimal width of fluidic gap, corresponding to a particular mode spot size. We will be also showing that the sensitivity of the biosensor is affected by efficiency of light coupling, which is influenced by changes in the width of fluidic gap, refractive index of the fluid and higher order modes.

Keywords

Couplings; Optical refraction; Optical sensors; Optical variables control; Optical waveguides; Organic light emitting diodes; Refractive index; Biosensing Techniques; Computer-Aided Design; Equipment Design; Equipment Failure Analysis; Light; Microfluidic Analytical Techniques; Optical Devices; Reproducibility of Results; Scattering, Radiation; Sensitivity and Specificity; Spectrometry, Fluorescence; Systems Integration;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE

Conference_Location

Boston, MA

ISSN

1557-170X

Print_ISBN

978-1-4244-4121-1

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2011.6089889

Filename

6089889