Title :
"Metabolic Control Analysis" from a Control Theoretic Perspective
Author :
Ingalls, Brian P.
Author_Institution :
Dept. of Appl. Math., Waterloo Univ., Ont.
Abstract :
A theory of control of biochemical systems developed by the theoretical biology community is interpreted from a control-theoretic point of view. This theory, known as metabolic control analysis (MCA), is based on an extension of parametric sensitivity analysis to stoichiometric systems. The main results of MCA are shown to correspond to particular solutions of an appropriately stated tracking problem. This presentation leads to some natural generalizations of existing results
Keywords :
biochemistry; biocontrol; sensitivity analysis; stoichiometry; biochemical system control theory; metabolic control analysis; parametric sensitivity analysis; stoichiometric system; theoretical biology community; tracking problem; Biochemical analysis; Biochemistry; Biological control systems; Control system analysis; Control systems; Feedback control; Mathematics; Sensitivity analysis; Steady-state; USA Councils;
Conference_Titel :
Decision and Control, 2006 45th IEEE Conference on
Conference_Location :
San Diego, CA
Print_ISBN :
1-4244-0171-2
DOI :
10.1109/CDC.2006.377367
