Validation of a preterm infant cardiovascular system model under baroreflex control with heart rate and blood pressure data

Author

Jennekens, Ward ; Dat, Marco ; Bovendeerd, Peter HM ; Wijn, Pieter FF ; Andriessen, Peter

Author_Institution

Department of Clinical Physics of the Máxima Medical Center, Veldhoven, The Netherlands and the Department of Applied Physics, Eindhoven University of Technology, Eindhoven, The Netherlands

fYear

2011

fDate

Aug. 30 2011-Sept. 3 2011

Firstpage

896

Lastpage

899

Abstract

In this paper we present an autonomic cardiovascular model of a preterm infant of 28 weeks of gestation with a birth weight of 1000 g and a closed ductus arteriosus by the end of the first week, that is capable of describing the complex interactions between heart rate, blood pressure and respiration. The hemodynamic model consists of a pulsatile heart and several vascular compartments, and is regulated by a baroreflex control system. The model is relatively simple to allow for a mathematical analysis of the dynamics but sufficiently complex to provide a realistic representation of the underlying physiology. The model provides (beat-to-beat) values of R-R interval and blood pressure that resemble realistic signals of preterm infants. The model is validated with experimental data obtained in preterm infants.

Keywords

Data models; Heart rate; Hemodynamics; Mathematical model; Pediatrics; Baroreflex; Blood Pressure; Computer Simulation; Heart Rate; Humans; Infant, Newborn; Infant, Premature; Male; Models, Cardiovascular; Reproducibility of Results; Sensitivity and Specificity;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE

Conference_Location

Boston, MA

ISSN

1557-170X

Print_ISBN

978-1-4244-4121-1

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2011.6090200

Filename

6090200