Title :
Dynamical model of P53-Mdm2-P14/19ARF network to radiation in population of cells
Author :
Liu, Hui ; Han, Yingrong ; Chen, Yafei ; Zhang, Suhua ; Zhao, Tongjun ; Zhan, Yong
Author_Institution :
Inst. of Biophys., Hebei Univ. of Technol., Tianjin, China
Abstract :
From the recent experiments of gamma radiation and models given before, we study the dynamical model of p53 and Mdm2 regulated by p14/19ARF in population of cells. In order to study how they infect the mechanism of the negative feedback loop, we give numerical results to study the oscillatory features of p53, Mdm2 and p14/19ARF in population of cells. The dynamical model and results will help us understand the oscillatory features of p53, Mdm2 and p14/19ARF to radiation in population of cells.
Keywords :
biocybernetics; biological effects of ionising radiation; cellular biophysics; feedback; oscillations; Mdm2 oscillatory features; P14-19ARF regulated Mdm2; P14-19ARF regulated P53; cell populations; negative feedback loop; network dynamical model; p14-19ARF oscillatory features; p53 oscillatory features; Cancer; DNA; Fellows; Gene expression; Genetic mutations; Negative feedback; Negative feedback loops; Neoplasms; Proteins; Stochastic processes; Dynamical Model; Mdm2; P14/19ARF; p53;
Conference_Titel :
Bio-Inspired Computing, 2009. BIC-TA '09. Fourth International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-3866-2
Electronic_ISBN :
978-1-4244-3867-9
DOI :
10.1109/BICTA.2009.5338108
