Title :
A whole-cell neurosensor: simulation of summed asynchronous neural activity
Author :
Gaumond, R. ; Moyer, J. ; Silva, R.
Author_Institution :
Bioeng. Dept., Pennsylvania State Univ., University Park, PA, USA
Abstract :
We describe a Markov chain representation for the summed asynchronous neural discharge currents of neurons grown on an electrode surface. We show that the spectrum of the recorded current signal can be used to characterize the type of neuron on the electrode
Keywords :
Markov processes; bioelectric potentials; biomedical electrodes; biosensors; cellular transport; neurophysiology; probability; Markov chain representation; asynchronous neural discharge currents; biosensor system; dorsal root ganglion; electrode surface grown neurons; minimal viable population; occupation probability; optimal electrode size; optimal number of cells; polymodal nociceptor neuron; recording bandwidth; resting potential; spectral representation; spike discharge rate; state transition probabilities; steady state probabilities; stochastic model; summed action potential signal; summed asynchronous neural activity; whole-cell neurosensor; Bandwidth; Biomedical engineering; Biosensors; Electrodes; Neurons; Signal design; Signal to noise ratio; Steady-state; Stochastic resonance; Surface discharges;
Conference_Titel :
Bioengineering Conference, 2002. Proceedings of the IEEE 28th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
0-7803-7419-3
DOI :
10.1109/NEBC.2002.999448
