Title :
Control aspects of left ventricular wall thickness in pressure overload left ventricular hypertrophy
Author :
Feng, Minjie ; Drzewiecki, Gary M. ; Li, John K-J.
Author_Institution :
Dept. of Biomed. Eng., Rutgers Univ., Piscataway, NJ, USA
Abstract :
A negative feedback control model was developed to predict left ventricular (LV) wall thickness growth over a long time period following the elevation of peak systolic pressure to prescribed values. Time series plots, phase plots and delay maps were obtained for both wall thickness growth with and without delay. LV wall thickness steady-state values were found to change proportionally to the peak systolic pressure
Keywords :
biocontrol; cardiology; haemodynamics; physiological models; time series; Laplace law; adaptive process; canine heart; delay concept; delay maps; increased hemodynamic loading; left ventricular wall thickness; long time period; mathematical model; myocardial fiber level; negative feedback control model; peak systolic pressure elevation; phase plots; pressure overload left ventricular hypertrophy; steady-state values; time series plots; Delay effects; Hemodynamics; Hypertension; Myocardium; Negative feedback; Negative feedback loops; Pressure control; Steady-state; Stress; Thickness control;
Conference_Titel :
Bioengineering Conference, 2002. Proceedings of the IEEE 28th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
0-7803-7419-3
DOI :
10.1109/NEBC.2002.999453
