Title :
Development and evaluation of a multi-wavelength multi-channel time resolved optical instrument for NIR/MRI mammography co-registration
Author :
Intes, Xavier ; Yu, Jiangsheng ; Yodh, Arjun G. ; Chance, Britton
Author_Institution :
Dept. of Biochem. & Biophys., Pennsylvania Univ., Philadelphia, PA, USA
Abstract :
We have developed a multi-channel/multi-wavelength photon counting instrument to perform near infrared diffuse optical spectroscopy and tomography simultaneously with a magnetic resonance scanner. The instrument has been tested with phantoms mimicking relevant breast configurations. Accuracy limits of absolute and relative optical properties determination are analyzed. Then, clinical in-vivo preliminary results are presented
Keywords :
bio-optics; biomedical MRI; image registration; infrared imaging; infrared spectroscopy; laser applications in medicine; mammography; medical image processing; optical tomography; photon counting; time resolved spectroscopy; tumours; turbidity; NIR/MRI mammography coregistration; absolute optical properties; accuracy limits; blood saturation; blood volume; breast phantoms; breast tumor; contrast agent; diffuse optical tomography; intrinsic chromophores; isotropic point source; magnetic resonance scanner; multichannel multiwavelength photon counting instrument; near infrared diffuse optical spectroscopy; noninvasive technology; photon density waves; photon migration; relative optical properties; time curve; time resolved optical instrument; turbid media; Biomedical optical imaging; Equations; Infrared spectra; Instruments; Mammography; Optical attenuators; Optical saturation; Optical scattering; Optical sensors; Single photon emission computed tomography;
Conference_Titel :
Bioengineering Conference, 2002. Proceedings of the IEEE 28th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
0-7803-7419-3
DOI :
10.1109/NEBC.2002.999480
