Title :
Design and assembly of a sterile nanoscale orthopedic biomaterial
Author :
Longsworth, John ; Eppell, Steven
Author_Institution :
Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA
Abstract :
This paper details the design and manufacture of a synthetic biomimetic bone biomaterial. The material is a composite of collagen fibrils and nanometer sized mineral apatites to enhance its resorbability over previous hydroxyapatite ceramics and bone cements. An aseptic protocol for producing a sterile composite has been developed and tested. It is now possible to use this biomaterial in cell experiments
Keywords :
biomedical materials; biomimetics; bone; composite materials; nanostructured materials; orthopaedics; proteins; self-assembly; aseptic protocol; biomimetic bone biomaterial; bone healing; collagen fibrils; collagen scaffold; composite biomaterial; nanometer sized mineral apatites; osteoclast cell cultures; resorbability; self-assembly protocol; sterile nanoscale orthopedic biomaterial; triple helical monomers; trypsin digestion; Assembly; Biological materials; Biomimetics; Bones; Building materials; Ceramics; Composite materials; Minerals; Orthopedic surgery; Pulp manufacturing;
Conference_Titel :
Bioengineering Conference, 2002. Proceedings of the IEEE 28th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
0-7803-7419-3
DOI :
10.1109/NEBC.2002.999521
