Title :
Surface modification of PLGA microspheres for targeting
Author :
Lathia, Justin D. ; El-Sherif, Dalia ; Dhoot, Nikhil O. ; Wheatley, Margaret A.
Author_Institution :
Sch. of Biomed. Eng., Sci. & Health Syst., Drexel Univ., Philadelphia, PA, USA
Abstract :
RGD peptide was conjugated to hollow microspheres to develop PLGA ultrasound contrast agents that enhance ultrasound imaging. The microcapsules were coated with an RGD peptide that targets integrins specific to angiogenesis, αvβ3 and αvβ5. The microcapsules were then bound to rat neuroblastoma cells in vitro within 6 hours. The RGD peptide modified microcapsules makes them ideal candidates for targeted therapeutic imaging and drug delivery vehicles
Keywords :
adhesion; biomedical materials; biomedical ultrasonics; cellular biophysics; drug delivery systems; gels; polymer blends; surface treatment; PLGA ultrasound contrast agents; RGD peptide conjugation; angiogenesis specific integrins; cells in vitro; cellular adhesion; double emulsion solvent evaporation; drug delivery; hollow microspheres; limited attachment; microsphere attachment; rat neuroblastoma cells in vitro; surface modification; targeting; therapeutic imaging; tumor growth; ultrasound imaging; vasculature formation; Biomedical engineering; Biomedical imaging; Cells (biology); Chemical engineering; Drug delivery; Peptides; Sequences; Targeted drug delivery; Ultrasonic imaging; Vehicles;
Conference_Titel :
Bioengineering Conference, 2002. Proceedings of the IEEE 28th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
0-7803-7419-3
DOI :
10.1109/NEBC.2002.999547
