Title :
Ultrasound induced degradation of hollow PLGA microcapsules
Author :
El-Sherif, Dalia ; Lathia, Justin ; Le, Ngocyen ; Wheatley, Margaret A.
Author_Institution :
Sch. of Biomed. Eng., Sci. & Health Syst., Drexel Univ., Philadelphia, PA, USA
Abstract :
We have investigated the effect of ultrasound energy on the degradation pattern of hollow PLGA microcapsules. These microcapsules work as ultrasound contrast agents, giving an in vitro acoustic enhancement of up to 25 dB. The dose response at 5 and 10 MHz was compared to the degradation pattern of the polymer capsules at the same two frequencies. Controlling the degradation is especially important with regard to drug-loaded microcapsules
Keywords :
biomedical materials; biomedical ultrasonics; drug delivery systems; polymer blends; ultrasonic effects; 10 MHz; 5 MHz; co-polymer; degradation pattern; dose response; drug release rates; drug-loaded microcapsules; hollow PLGA microcapsules; n vitro acoustic enhancement; noninvasive targeted drug delivery systems; poly(D,L-lactide-co-glycolic acid); ultrasound contrast agents; ultrasound energy; ultrasound induced degradation; Biomedical engineering; Chemical engineering; Chemical transducers; Drugs; Frequency; In vitro; Polymers; Scanning electron microscopy; Thermal degradation; Ultrasonic imaging;
Conference_Titel :
Bioengineering Conference, 2002. Proceedings of the IEEE 28th Annual Northeast
Conference_Location :
Philadelphia, PA
Print_ISBN :
0-7803-7419-3
DOI :
10.1109/NEBC.2002.999550
