Locomotor recovery promoted by sensorimotor training and the graft of fibroblasts genetically engineered to produce BDNF and NT3 in the injured cat spinal cord

Author

Bhowmik, Manoshi ; Tobias, Chris A. ; Fischer, Itzhak ; Murray, Marion ; Lemay, Michel A.

Author_Institution

Dept. of Neurobiol. & Anatomy, Hahnemann Univ., Philadelphia, PA, USA

fYear

2002

fDate

2002

Firstpage

233

Lastpage

234

Abstract

Studies that have compared locomotion in the adult cat hindlimb before and after spinal transection have found that "despite a few differences, the spinal cord and the hind limbs afferents are capable of generating very good locomotor patterns with almost normal kinematics" when the animals are submitted to a daily regimen of treadmill walking. We are trying to enhance motor recovery in the hindlimbs by promoting axonal regeneration through the implantation of fibroblasts genetically modified to produce neurotrophins

Keywords

biomechanics; kinematics; neurophysiology; prosthetics; surgery; BDNF transplants; NT3 transplants; adult cat hindlimb; angle motion; axonal regeneration; end-point motion; genetically engineered fibroblast graft; injured cat spinal cord; kinematic information; locomotor recovery; neurotrophins; sensorimotor training; transplant therapies; treadmill training; walking; Anesthesia; Animals; Cats; Engines; Fibroblasts; Genetic engineering; Legged locomotion; Monitoring; Spinal cord; Surgery;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2002. Proceedings of the IEEE 28th Annual Northeast

Conference_Location

Philadelphia, PA

Print_ISBN

0-7803-7419-3

Type

conf

DOI

10.1109/NEBC.2002.999551

Filename

999551