Probing for cortical excitability

Author

Freestone, Dean R. ; Burkitt, Anthony N. ; Lai, Alan ; Nelson, Timothy S. ; Grayden, David B. ; Vogrin, Simon ; Murphy, Michael ; Souza, Wendyl D. ; Badawy, Radwa ; Kuhlmann, Levin ; Cook, Mark J.

Author_Institution

Dept. of Electr. & Electron. Eng., Univ. of Melbourne, Melbourne, VIC, Australia

fYear

2011

fDate

Aug. 30 2011-Sept. 3 2011

Firstpage

1644

Lastpage

1647

Abstract

This paper introduces a new method for measuring cortical excitability using an electrical probing stimulus via intracranial electroencephalography (iEEG). Stimuli consisted of 100 single bi-phasic pulses, delivered every 10 minutes. Neural excitability is estimated by extracting a feature from the iEEG responses to the stimuli, which we dub the mean phase variance (PV). We show that the mean PV increases with the rate of interictal discharges in one patient. In another patient, we show that the mean PV changes with sleep and an epileptic seizure. The results demonstrate a proof-of-principal for the method to be applied in a seizure anticipation framework.

Keywords

diseases; electroencephalography; feature extraction; medical signal processing; neurophysiology; sleep; cortical excitability measurement; electrical probing stimulus; epileptic seizure; iEEG; intracranial electroencephalography; mean phase variance; neural excitability; seizure anticipation framework; single biphasic pulses; sleep; Discharges; Electrical stimulation; Electrodes; Electroencephalography; Epilepsy; Phase measurement; Temporal lobe; Algorithms; Cerebral Cortex; Diagnosis, Computer-Assisted; Electric Stimulation; Electroencephalography; Epilepsy; Humans; Nerve Net; Reproducibility of Results; Sensitivity and Specificity;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE

Conference_Location

Boston, MA

ISSN

1557-170X

Print_ISBN

978-1-4244-4121-1

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2011.6090474

Filename

6090474