Title :
Probing for cortical excitability
Author :
Freestone, Dean R. ; Burkitt, Anthony N. ; Lai, Alan ; Nelson, Timothy S. ; Grayden, David B. ; Vogrin, Simon ; Murphy, Michael ; Souza, Wendyl D. ; Badawy, Radwa ; Kuhlmann, Levin ; Cook, Mark J.
Author_Institution :
Dept. of Electr. & Electron. Eng., Univ. of Melbourne, Melbourne, VIC, Australia
fDate :
Aug. 30 2011-Sept. 3 2011
Abstract :
This paper introduces a new method for measuring cortical excitability using an electrical probing stimulus via intracranial electroencephalography (iEEG). Stimuli consisted of 100 single bi-phasic pulses, delivered every 10 minutes. Neural excitability is estimated by extracting a feature from the iEEG responses to the stimuli, which we dub the mean phase variance (PV). We show that the mean PV increases with the rate of interictal discharges in one patient. In another patient, we show that the mean PV changes with sleep and an epileptic seizure. The results demonstrate a proof-of-principal for the method to be applied in a seizure anticipation framework.
Keywords :
diseases; electroencephalography; feature extraction; medical signal processing; neurophysiology; sleep; cortical excitability measurement; electrical probing stimulus; epileptic seizure; iEEG; intracranial electroencephalography; mean phase variance; neural excitability; seizure anticipation framework; single biphasic pulses; sleep; Discharges; Electrical stimulation; Electrodes; Electroencephalography; Epilepsy; Phase measurement; Temporal lobe; Algorithms; Cerebral Cortex; Diagnosis, Computer-Assisted; Electric Stimulation; Electroencephalography; Epilepsy; Humans; Nerve Net; Reproducibility of Results; Sensitivity and Specificity;
Conference_Titel :
Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-4121-1
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2011.6090474
