Title :
11A-3 A Novel Sensitive Targeted Imaging Technique for Ultrasonic Molecular Imaging
Author :
Zheng, Hairong ; Kruse, Dustin E. ; Stephens, Douglas N. ; Ferrara, Katherine W. ; Sutcliffe, Patrick ; Gardner, Edward
Author_Institution :
Univ. of California, Davis
Abstract :
We have recently developed a targeted imaging technique for selective and sensitive ultrasound molecular imaging by taking advantage of wideband transient high frequency acoustic emission from ultrasound contrast agents. The imaging modality makes use of a novel multi-frequency co-linear array (two outer 1.4 MHz and one center 5.3 MHz arrays) transducer integrated with the Siemens Antares System. The imaging sequence includes a B-mode imaging pulse sequence in which a short pulse is transmitted with the outer low frequency arrays and received with the inner high frequency array (TLRH: transmit at low frequency and receive at high frequency), followed by a long radiation force pulse to induce immediate bubble adhesion using the center array, and a second B-mode imaging pulse sequence. The RF data obtained from the second B-mode pulse sequence are averaged and then subtracted from the first B-mode sequence. The imaging technique was tested in a targeted imaging phantom, where lipid-shelled biotin microbubbles flow within an avidin coated-cellulose. Results showed that tissue signals were suppressed up to 33 dB and a targeted bubble contrast-to-free bubble signal ratio of up to 23 dB was obtained from the composite sequence imaging.
Keywords :
acoustic emission; biomedical ultrasonics; molecular biophysics; phantoms; ultrasonic imaging; B-mode imaging; Siemens Antares System; frequency 1.4 MHz; frequency 5.3 MHz; high frequency acoustic emission; imaging phantom; sensitive ultrasonic molecular imaging; targeted imaging technique; Acoustic emission; Acoustic imaging; Acoustic pulses; Acoustic transducers; Adhesives; Frequency; Molecular imaging; Ultra wideband technology; Ultrasonic imaging; Ultrasonic transducers;
Conference_Titel :
Ultrasonics Symposium, 2007. IEEE
Conference_Location :
New York, NY
Print_ISBN :
978-1-4244-1384-3
Electronic_ISBN :
1051-0117
DOI :
10.1109/ULTSYM.2007.244