Regularity analysis of spontaneous MEG activity in Attention-Deficit/Hyperactivity Disorder

Author

Gómez, Carlos ; Poza, Jesús ; García, María ; Fernández, Alberto ; Hornero, Roberto

Author_Institution

Dept. of Signal Theor. & Commun., Univ. of Valladolid, Valladolid, Spain

fYear

2011

fDate

Aug. 30 2011-Sept. 3 2011

Firstpage

1765

Lastpage

1768

Abstract

The aim of this study was to analyze the magnetoencephalography (MEG) background activity in Attention-Deficit/Hyperactivity Disorder (ADHD) using a regularity measure: sample entropy (SampEn). Five minutes of recording were acquired with a 148-channel whole-head magnetometer in 14 ADHD patients and 14 control subjects. Our results showed that ADHD patients´ MEGs were more regular than controls´ recordings. Additionally, there were statistically significant differences (p <; 0.01, Student´s t-test with Bonferroni´s correction) at the five analyzed brain areas: anterior, central, posterior, left lateral and right lateral. Using receiver operating characteristic (ROC) curves, the highest accuracy (82.14%) was achieved at posterior region, whereas the highest area under the ROC curves (0.8827) were reached at anterior and central brain regions. These results suggest the usefulness of SampEn to reveal an abnormal type of dynamics associated with ADHD.

Keywords

magnetoencephalography; magnetometers; medical disorders; sensitivity analysis; 148-channel whole-head magnetometer; ADHD patient; ROC curves; SampEn; anterior brain area; attention-deficit-hyperactivity disorder; left lateral brain area; magnetoencephalography background activity; posterior brain area; receiver operating characteristic curves; regularity analysis; right lateral brain area; sample entropy; spontaneous MEG activity; student t-test; Brain; Electroencephalography; Entropy; Magnetic noise; Magnetometers; Time series analysis; Adolescent; Algorithms; Attention Deficit Disorder with Hyperactivity; Biological Clocks; Brain; Diagnosis, Computer-Assisted; Female; Humans; Magnetoencephalography; Male; Pattern Recognition, Automated; Reproducibility of Results; Sensitivity and Specificity;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE

Conference_Location

Boston, MA

ISSN

1557-170X

Print_ISBN

978-1-4244-4121-1

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2011.6090504

Filename

6090504