• DocumentCode
    2476447
  • Title

    A novel and efficient synthesis of 3′-amino-3′-deoxyadenosine

  • Author

    Chen, Wei ; Qian, Xin-Ming ; He, Xue-Qiu ; Peng, Tao

  • Author_Institution
    State Key Lab. of Explosion Sci. & Technol., Beijing Inst. of Technol., Beijing, China
  • fYear
    2011
  • fDate
    24-26 June 2011
  • Firstpage
    7318
  • Lastpage
    7321
  • Abstract
    A novel method for efficient synthesis of 3´amino-3´ deoxyadenosine from adenosine was developed. Adenosine was reacted with triethyl orthoacetate and then acetyl bromide to afford 2´, 5´-0-acetyl-3´-bromo-3´-deoxyadenosine, which reacted with N-benzyl-4-nitrobenzenesulfonamide and then with thiophenol to yield 3´-(benzylamino)-3´-deoxy-adenosine. Following treated with Pd/C and H2, 3´-amino-3´-deoxyadenosine was synthesized. This method was facile and efficient.
  • Keywords
    chemical engineering; hydrogen compounds; palladium compounds; 3-amino-3-deoxyadenosine; N-benzyl-4-nitrobenzenesulfonamide; acetyl bromide; adenosine; adenosine synthesis; thiophenol; triethyl orthoacetate; Chemicals; Nuclear magnetic resonance; Proteins; Silicon compounds; Solids; Suspensions; 3′-Amino-3′- deoxyadenosine; Adenosine; Meisenheimer; N-benzyl-4-nitrobenzenesulfonamide;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Remote Sensing, Environment and Transportation Engineering (RSETE), 2011 International Conference on
  • Conference_Location
    Nanjing
  • Print_ISBN
    978-1-4244-9172-8
  • Type

    conf

  • DOI
    10.1109/RSETE.2011.5966058
  • Filename
    5966058
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=2476447