Title :
Cr(VI) with curcumin and hydrogen peroxide causes DNA damage
Author :
Zhang, Jun ; Shi, Xiaoting ; Yang, Hong ; Zhang, Zhong
Author_Institution :
Sch. of Chem. & Chem. Eng., Inner Mongolia Univ., Hohhot, China
Abstract :
DNA conformational change and breakage induced by Cr(VI) and curcumin in the present of H2O2 were characterized by the atomic force microscopy. Incubation of DNA with curcumin and Cr(VI) in the presence of H2O2 caused DNA double-strand breaks significantly. Cr(VI) and H2O2 also breaked mildly DNA double-strands. On the basis of these results, we think hydroxyl radicals and reactive oxygen species can play a principal role in this DNA damage system.
Keywords :
DNA; atom-molecule reactions; atomic force microscopy; biochemistry; biological techniques; chromium; free radicals; hydrogen compounds; molecular biophysics; molecular configurations; molecule-molecule reactions; Cr; DNA breakage; DNA conformational change; DNA damage; DNA double strand breakage; H2O2; atomic force microscopy; chromium; curcumin; hydrogen peroxide; hydroxyl radical; incubation; reactive oxygen species; Atomic force microscopy; Atomic measurements; DNA; Force; Humans; Metals; Cr(VI) double-strand; DNA break; curcumin;
Conference_Titel :
Remote Sensing, Environment and Transportation Engineering (RSETE), 2011 International Conference on
Conference_Location :
Nanjing
Print_ISBN :
978-1-4244-9172-8
DOI :
10.1109/RSETE.2011.5966098
