• DocumentCode
    2478927
  • Title

    Robustness of inverse perturbation for discrete event control

  • Author

    Bouaynaya, Nidhal ; Shterenberg, Roman ; Schonfeld, Dan

  • Author_Institution
    Dept. of Syst. Eng., Univ. of Arkansas at Little Rock, Little Rock, AR, USA
  • fYear
    2011
  • fDate
    Aug. 30 2011-Sept. 3 2011
  • Firstpage
    2422
  • Lastpage
    2425
  • Abstract
    We study the robustness of the inverse perturbation solution in discrete-time systems modeled by homogeneous Markov chains. We cast the optimal inverse perturbation control as a strictly convex optimization problem, which admits a unique global solution. We show that the optimal inverse perturbation control is robust to estimation errors in the original network. The derived results are applied to the Human melanoma gene regulatory network, where the aim is to force the network to converge to a desired steady-state distribution of gene regulation.
  • Keywords
    Markov processes; biocontrol; convex programming; discrete event systems; discrete time systems; genetics; optimal control; perturbation techniques; robust control; discrete event control; discrete-time system; homogeneous Markov chains; human melanoma gene regulatory network; inverse perturbation solution; optimal inverse perturbation control; robustness; steady-state distribution; strictly convex optimization problem; Convex functions; Estimation error; Humans; Malignant tumors; Markov processes; Robustness; Steady-state; Finite Markov chains; Inverse perturbation; Perturbation theory; robustness; stability; Computer Simulation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Markov Chains; Melanoma; Models, Biological; Models, Statistical; Neoplasm Proteins;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
  • Conference_Location
    Boston, MA
  • ISSN
    1557-170X
  • Print_ISBN
    978-1-4244-4121-1
  • Electronic_ISBN
    1557-170X
  • Type

    conf

  • DOI
    10.1109/IEMBS.2011.6090674
  • Filename
    6090674