DocumentCode
2478927
Title
Robustness of inverse perturbation for discrete event control
Author
Bouaynaya, Nidhal ; Shterenberg, Roman ; Schonfeld, Dan
Author_Institution
Dept. of Syst. Eng., Univ. of Arkansas at Little Rock, Little Rock, AR, USA
fYear
2011
fDate
Aug. 30 2011-Sept. 3 2011
Firstpage
2422
Lastpage
2425
Abstract
We study the robustness of the inverse perturbation solution in discrete-time systems modeled by homogeneous Markov chains. We cast the optimal inverse perturbation control as a strictly convex optimization problem, which admits a unique global solution. We show that the optimal inverse perturbation control is robust to estimation errors in the original network. The derived results are applied to the Human melanoma gene regulatory network, where the aim is to force the network to converge to a desired steady-state distribution of gene regulation.
Keywords
Markov processes; biocontrol; convex programming; discrete event systems; discrete time systems; genetics; optimal control; perturbation techniques; robust control; discrete event control; discrete-time system; homogeneous Markov chains; human melanoma gene regulatory network; inverse perturbation solution; optimal inverse perturbation control; robustness; steady-state distribution; strictly convex optimization problem; Convex functions; Estimation error; Humans; Malignant tumors; Markov processes; Robustness; Steady-state; Finite Markov chains; Inverse perturbation; Perturbation theory; robustness; stability; Computer Simulation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Markov Chains; Melanoma; Models, Biological; Models, Statistical; Neoplasm Proteins;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
Conference_Location
Boston, MA
ISSN
1557-170X
Print_ISBN
978-1-4244-4121-1
Electronic_ISBN
1557-170X
Type
conf
DOI
10.1109/IEMBS.2011.6090674
Filename
6090674
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