System Dynamics of Chronic Hepatitis B - Modeling the Virus and Immune System of Chronic Hepatitis B

Author

Long, Changjiang ; Qi, Huan ; Peng, Wan

Author_Institution

Coll. of Eng. & Technol., Huazhong Agric. Univ., Wuhan, China

fYear

2010

fDate

22-23 May 2010

Firstpage

1

Lastpage

4

Abstract

The pathogenesis of chronic hepatitis B is very complex, Systems biology can help us understand it by considering the body, virus and immune system as a whole. Mathematical model including HBV, hepatocytes and the immune system was established in this paper describing the interaction of virus and immune system. The model considered not only the side that hepatitis B virus can evoke the immune system, but also the other side that hepatitis B virus can suppress the immune function by leading a high death rate of hepatitis B virus-specific Cytotoxic T lymphocytes (CTLs). The condition why the immune system fails to eliminate the virus is explained by an inequality. Four kinds of chronic hepatitis, including acute-turn-chronic hepatitis, chronic hepatitis without acute phase, recurring hepatitis and chronic hepatitis (infected at birth) were simulated to show the natural history of chronic hepatitis.

Keywords

cellular biophysics; diseases; kidney; microorganisms; physiological models; HBV; acute turn chronic hepatitis; chronic hepatitis B; cytotoxic T lymphocytes; death rate; hepatitis B virus; hepatocytes; immune system; mathematical model; recurring hepatitis; system biology; system dynamics; Agricultural engineering; Biological system modeling; Educational institutions; Immune system; Injuries; Liver diseases; Mathematical model; Pathogens; Pediatrics; Systems biology;

fLanguage

English

Publisher

ieee

Conference_Titel

Intelligent Systems and Applications (ISA), 2010 2nd International Workshop on

Conference_Location

Wuhan

Print_ISBN

978-1-4244-5872-1

Electronic_ISBN

978-1-4244-5874-5

Type

conf

DOI

10.1109/IWISA.2010.5473320

Filename

5473320