Handheld bio-impedance measurement system based on an instrument-on-chip

Author

Rottigni, Angelo ; Carminati, Marco ; Ferrari, Giorgio ; Sampietro, Marco

Author_Institution

Dipt. di Elettron. e Inf., Politec. di Milano, Milan, Italy

fYear

2011

fDate

3-7 July 2011

Firstpage

49

Lastpage

52

Abstract

In this paper we present a compact system for impedance measurement in the kHz-MHz frequency range with attoFarad resolution. It has been designed to address micro- and nano-scale bio-sensing applications, such as impedimetric flow cytometry or molecular affinity bio-sensors. The core of the detection system is an integrated circuit that features a low noise current amplifier, a two-phase square waveform lock-in detector and two ΣΔ analog-to-digital converters. The CMOS chip is complemented by all the blocks needed to perform spectroscopy measurements, including versatile signal generation, digital processing and PC data transmission. The whole stand-alone system is USB powered and can reach sub-fF resolution in capacitive tracking on a sub-millisecond time scale.

Keywords

CMOS integrated circuits; biosensors; electric impedance measurement; lab-on-a-chip; low noise amplifiers; microsensors; nanosensors; peripheral interfaces; sigma-delta modulation; ΣΔ analog-to-digital converters; CMOS chip; PC data transmission; USB; attoFarad resolution; detection system; digital processing; handheld bioimpedance measurement system; impedimetric flow cytometry; instrument-on-chip; integrated circuit; lab-on- a-chip; low noise current amplifier; microscale biosensing; molecular affinity biosensors; nanoscale biosensing; spectroscopy measurements; two-phase square waveform lock-in detector; versatile signal generation; CMOS integrated circuits; Capacitance; Frequency measurement; Impedance; Impedance measurement; Instruments; Noise; CMOS Lock-in; Impedance spectroscopy; Lab-ona-Chip;

fLanguage

English

Publisher

ieee

Conference_Titel

Ph.D. Research in Microelectronics and Electronics (PRIME), 2011 7th Conference on

Conference_Location

Trento

Print_ISBN

978-1-4244-9138-4

Electronic_ISBN

978-1-4244-9136-0

Type

conf

DOI

10.1109/PRIME.2011.5966214

Filename

5966214