Effects of countershock-type field stimulation on the electromechanical properties of guinea pig ventricular muscles

Author

Iida, M. ; Kodama, I. ; Suzuki, R. ; Shibata, N. ; Satoh, Y. ; Fukui, Y. ; Toyama, J.

Author_Institution

Res. Inst. of Environ. Med., Nagoya Univ., Japan

fYear

1991

fDate

23-26 Sep 1991

Firstpage

529

Lastpage

532

Abstract

The authors investigated the effects of countershock-type electric field stimulation of various intensities on transmembrane action potentials and isometric contraction in isolated guinea pig ventricular muscles. Since increases of developed tension and resting tension were often noted immediately after the field stimulation, it is reasonable to speculate that the stimulation might alter intracellular calcium concentration. Therefore, another purpose of the study was to examine the influences of nifedipine, a potent inhibitor of the voltage dependent calcium channel, and of ryanodine, an inhibitor of the sarcoplasmic reticuulum calcium release. The results have revealed that countershock-type high-intensity electric field stimulation causes prolonged depolarization and spontaneous activity in guinea pig ventricular muscles

Keywords

bioelectric phenomena; biological effects of fields; biomechanics; cardiology; electric field effects; countershock-type field stimulation; developed tension; electromechanical properties; guinea pig ventricular muscles; high-intensity electric field stimulation; intracellular Ca²⁺ concentration; isometric contraction; nifedipine; prolonged depolarization; resting tension; ryanodine; spontaneous activity; transmembrane action potentials; Biomembranes; Calcium; Electric shock; Electrodes; Glass; Heart; Inhibitors; Muscles; Platinum; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology 1991, Proceedings.

Conference_Location

Venice

Print_ISBN

0-8186-2485-X

Type

conf

DOI

10.1109/CIC.1991.168964

Filename

168964