Computer model of propagated excitation in the anisotropic human heart. I. Implementation and algorithms

The authors have developed a computer model of propagated excitation in the three-dimensional anisotropic human ventricular myocardium. The model employs both the differential-equation approach and the cellular-automata approach in simulating cardiac propagation phenomena. Electrotonic interaction of the model´s excitable elements is governed by a parabolic partial differential equation derived from the anisotropic biodomain theory; their suprathreshold behavior, however, is largely determined by the state-transition rules of the cellular automaton