The response of hepatocyte cell volume to hyperthermia and its role in oedema

Author

O´Neill, D.P. ; Peng, T. ; Payne, S.J.

Author_Institution

Dept. of Eng. Sci., Univ. of Oxford, Oxford, UK

fYear

2011

fDate

Aug. 30 2011-Sept. 3 2011

Firstpage

4305

Lastpage

4308

Abstract

A novel mathematical model for hepatocytes and surrounding volume is presented here; in addition to tracking ion transport and diffusion the new model allows for changing cell volume. Using temporally and spatially varying temperature as an input, this paper shows how differences between diffusion coefficients directly influence increases in cell volume. The multiscale nature of the model presents a possible link from established cellular equations to the observed clinical result of oedema present in thermal treatments of cancer.

Keywords

biodiffusion; bioelectric phenomena; biomembrane transport; cancer; cellular biophysics; hyperthermia; liver; medical disorders; physiological models; cancer thermal treatments; cellular equations; changing cell volume; diffusion coefficients; hepatocyte cell volume hyperthermia response; hepatocyte mathematical model; ion diffusion; ion transport; oedema; spatially varying temperature; temporally varying temperature; Adaptation models; Equations; Extracellular; Ions; Liver; Mathematical model; Solid modeling; Cell Size; Edema; Fever; Humans; Models, Theoretical;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE

Conference_Location

Boston, MA

ISSN

1557-170X

Print_ISBN

978-1-4244-4121-1

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2011.6091069

Filename

6091069