Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves

Author

Tuan, Hoang-Trong Minh ; Williams, George S B ; Chikando, Aristide C. ; Sobie, Eric A. ; Lederer, W. Jonathan ; Jafri, M. Saleet

Author_Institution

Sch. of Syst. Biol., George Mason Univ., Manassas, VA, USA

fYear

2011

fDate

Aug. 30 2011-Sept. 3 2011

Firstpage

4677

Lastpage

4680

Abstract

A three dimensional model of calcium dynamics in the rat ventricular myocyte was developed to study the mechanism of calcium homeostasis and pathological calcium dynamics during calcium overload. The model contains 20,000 calcium release units (CRUs) each containing 49 ryanodine receptors. The model simulates calcium sparks with a realistic spontaneous calcium spark rate. It suggests that in addition to the calcium spark-based leak, there is an invisible calcium leak caused by the stochastic opening of a small number of ryanodine receptors in each CRU without triggering a calcium spark. The model also explores the mechanism of calcium wave propagation between release sites under the conditions of calcium overload.

Keywords

cardiology; cellular biophysics; stochastic processes; wave propagation; 3D model; calcium homeostasis; calcium spark-based leak; calcium wave propagation; cardiac ventricular myocyte calcium dynamics; pathological calcium dynamics; rat ventricular myocyte; ryanodine receptors; stochastic opening; stochastic simulation; Calcium; Computational modeling; Graphics processing unit; Mathematical model; Sparks; Stochastic processes; Strontium; Animals; Calcium; Heart Ventricles; Models, Theoretical; Rats; Stochastic Processes;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE

Conference_Location

Boston, MA

ISSN

1557-170X

Print_ISBN

978-1-4244-4121-1

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2011.6091158

Filename

6091158