Title :
Calibrating the photo-thermal response of magneto-fluorescent gold nanoshells
Author :
Biswal, Nrusingh C. ; Ayala-Orzoco, Ciceron ; Halas, Naomi J. ; Joshi, Amit
Author_Institution :
Dept. of Radiol., Baylor Coll. of Med., Houston, TX, USA
fDate :
Aug. 30 2011-Sept. 3 2011
Abstract :
We report the photothermal response and Near Infrared (NIR) imaging sensitivities of magneto-fluorescent silica core gold nanocomplexes designed for molecular image guided thermal therapy of cancer. Approximately 160 nm Silica core gold nanoshells were designed to provide NIR fluorescent and Magnetic Resonance (MR) contrast by incorporating FDA approved dye indocyanine green (ICG) and iron-oxide within an outer silica epilayer. The imaging and therapeutic sensitivity, and the stability of fluorescence contrast for 12 microliters of suspension (containing approximately 7.9 × 108 or 1.3 femtoMole nanoshells) buried at depths of 2-8 mm in tissue mimicking scattering media is reported.
Keywords :
biomedical MRI; biomedical optical imaging; cancer; dyes; fluorescence spectroscopy; gold; hyperthermia; infrared imaging; iron compounds; magnetic particles; nanobiotechnology; nanocomposites; nanoparticles; photothermal effects; ICG; NIR fluorescent contrast; NIR imaging sensitivities; SiO2-Au; SiO2-FeO; cancer therapy; core-shell nanoparticles; fluorescence contrast stability; imaging sensitivity; indocyanine green; magnetic resonance contrast; magnetofluorescent gold nanoshells; molecular image guided thermal therapy; near infrared imaging sensitivities; outer silica epilayered iron oxide; photothermal response calibration; silica core-gold shell nanocomplexes; suspension; therapeutic sensitivity; tissue mimicking scattering media; Cancer; Gold; Medical treatment; Phantoms; Scattering; Silicon compounds; Calibration; Ferric Compounds; Fluorescence; Gold; Indocyanine Green; Magnetic Resonance Spectroscopy; Magnetics; Nanostructures;
Conference_Titel :
Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-4121-1
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2011.6091183
