Detecting failures of the glucose sensor-insulin pump system: Improved overnight safety monitoring for Type-1 diabetes

Author

Facchinetti, Andrea ; Favero, Simone Del ; Sparacino, Giovanni ; Cobelli, Claudio

Author_Institution

Dept. of Inf. Eng., Univ. of Padova, Padova, Italy

fYear

2011

fDate

Aug. 30 2011-Sept. 3 2011

Firstpage

4947

Lastpage

4950

Abstract

New sensors for real-time continuous glucose monitoring (CGM) and pumps for continuous subcutaneous insulin infusion (CSII), possibly mounted on the same device, opened new scenarios for Type-1 diabetes treatment. However, possible failures of either CGM or CSII can expose diabetic patients to risks that can be dangerous especially overnight. In this contribution we present a proof-of-concept method, developed in a state-space context and implemented through a Kalman estimator, to detect in real time possible overnight failures of the sensor-pump system by simultaneously using CGM and CSII data. The method is tested on two simulated and one real subject. Results show that the method is able to correctly generate alerts for sensor-pump failures and stimulates further investigation on its development.

Keywords

Kalman filters; biochemistry; biomedical equipment; chemical sensors; diseases; patient monitoring; patient treatment; pumps; skin; state-space methods; sugar; Kalman estimator; continuous subcutaneous insulin infusion; glucose sensor-insulin pump system; overnight safety monitoring; proof-of-concept method; real time continuous glucose monitoring; sensor-pump failure; sensor-pump system; state-space development; type-1 diabetes treatment; Diabetes; Frequency division multiplexing; Insulin; Kalman filters; Plasmas; Sensors; Sugar; Blood Glucose Self-Monitoring; Diabetes Mellitus, Type 1; Diagnosis, Computer-Assisted; Drug Therapy, Computer-Assisted; Equipment Failure; Equipment Failure Analysis; Humans; Insulin Infusion Systems; Patient Safety; Pattern Recognition, Automated; Reproducibility of Results; Safety Management; Sensitivity and Specificity;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE

Conference_Location

Boston, MA

ISSN

1557-170X

Print_ISBN

978-1-4244-4121-1

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2011.6091226

Filename

6091226