Effect of a hyperpolarization-activated inward current on rhythmic activity in a hybrid half-center oscillator

Author

Sorensen, Michael ; Cymbalyuk, Gennady ; Calabrese, Ron ; DeWeerth, S.

Author_Institution

Lab. for Neuroengineering, Emory Univ., Atlanta, GA, USA

Volume

3

fYear

2002

fDate

23-26 Oct. 2002

Firstpage

2074

Abstract

A hybrid half-center oscillator, composed of a living neuron and an analog very large scale integrated circuit (aVLSI) model neuron connected via dynamic clamp has been constructed. This hybrid oscillator is designed to mimic the behavior of a living half-center found in Hirudo medicinalis, the medicinal leech. Using our hybrid system, we have investigated the effect of modulating a hyperpolarization-activated inward current on the oscillatory properties of the half-center.

Keywords

VLSI; bioelectric phenomena; biological techniques; neurophysiology; oscillators; Hirudo medicinalis; analog very large scale integrated circuit; dynamic clamp; half-center; hybrid half-center oscillator; hybrid systems; hyperpolarization-activated inward current; medicinal leech; oscillatory properties; rhythmic activity; Biological neural networks; Clamps; Integrated circuit modeling; Integrated circuit technology; Laboratories; Nerve fibers; Neural engineering; Neurons; Oscillators; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1053174

Filename

1053174