Electrophysiological Biosensor with Micro Channel Array for Sensing of Signals from Single Cells

This paper describes a novel electrophysiological biosensor with micro channel array (hereafter MCA) for sensing of signals from individual single cells. By using microelectromechanical systems (MEMS) technologies, we have developed the batch-measurement biosensor with MCA for sensing of electrophysiological signals gathered from single cells. We design the multipoint-measurement biosensor with MCA for observation of individual single cells. Detecting electrodes of the multipoint-measurement biosensor with MCA are independent from each other in order to analyze individual single cells. Biosensors with MCA employ the measurement principles of the patch-clamp technique. In this study, we evaluate electrophysiological signals of the mPerl-luc slice culture in response to chemical stimulus by the multipoint-measurement biosensor with MCA.