Title :
Modeling biochemical networks and excitation-contraction coupling
Author :
Saucerman, J.J. ; Michailova, A.P. ; McCulloch, D.
Author_Institution :
Dept. of Bioeng., Univ. of California, San Diego, CA, USA
Abstract :
Integrative computational models are being developed to couple biochemical networks with the physiological functions that they regulate. Models of interacting cell sub-systems including signal transduction, electrophysiology and metabolism are presented. These models allow us to explore hypotheses regarding physiological and pathophysiological function in the cardiac myocyte.
Keywords :
biochemistry; bioelectric phenomena; calcium; cardiology; muscle; physiological models; Ca; biochemical networks modeling; cardiac myocyte; electrophysiology; excitation-contraction coupling; heart muscle cells; interacting cell sub-systems models; metabolism; pathophysiological function; physiological functions regulation; Biochemical analysis; Biochemistry; Biomedical computing; Biomedical engineering; Biophysics; Calcium; Computer networks; Kinetic theory; Proteins; Regulators;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1053258
