Title :
Modeling wound healing: effects of cell heterogeneity and tissue structure
Author :
Mani, S. ; Zygourakis, K. ; Markenscoff, P.
Author_Institution :
Dept. of Electr. & Comput. Eng., Houston Univ., TX, USA
Abstract :
Cellular automata models are developed to simulate wound healing in tissues consisting of two cell populations, each with its own distinct migratory, proliferative and death characteristics. Simulation results show that both the growth rates and the composition of regenerated tissues depend very strongly on the migration speeds and the initial spatial distribution of the cells.
Keywords :
biological tissues; cellular automata; cellular transport; medical computing; physiological models; cell death characteristics; cell heterogeneity; cell migration speeds; cell migratory characteristics; cell populations; cell proliferative characteristics; cellular automata models; initial cell spatial distribution; regenerated tissues; tissue structure; wound healing modelling; Automata; Chemical engineering; Computational modeling; Computer simulation; Density functional theory; Matrices; Predictive models; Random variables; Regeneration engineering; Wounds;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1053260
