Modeling wound healing: effects of cell heterogeneity and tissue structure

Author

Mani, S. ; Zygourakis, K. ; Markenscoff, P.

Author_Institution

Dept. of Electr. & Comput. Eng., Houston Univ., TX, USA

Volume

3

fYear

2002

fDate

23-26 Oct. 2002

Firstpage

2239

Abstract

Cellular automata models are developed to simulate wound healing in tissues consisting of two cell populations, each with its own distinct migratory, proliferative and death characteristics. Simulation results show that both the growth rates and the composition of regenerated tissues depend very strongly on the migration speeds and the initial spatial distribution of the cells.

Keywords

biological tissues; cellular automata; cellular transport; medical computing; physiological models; cell death characteristics; cell heterogeneity; cell migration speeds; cell migratory characteristics; cell populations; cell proliferative characteristics; cellular automata models; initial cell spatial distribution; regenerated tissues; tissue structure; wound healing modelling; Automata; Chemical engineering; Computational modeling; Computer simulation; Density functional theory; Matrices; Predictive models; Random variables; Regeneration engineering; Wounds;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1053260

Filename

1053260