Title :
Detection of Receptor-Ligand Interactions with an GHz Impedance Biosensor System
Author :
Schlecht, U. ; Gronewold, T.M.A. ; Malavé, A. ; Tewes, M. ; Löhndorf, M.
Author_Institution :
Center of Adv. European Studies & Res., Bonn
Abstract :
Nanogap impedance biosensors with electrode separation of 75 nm have been used for the specific detection of biological interactions. Different model systems, such as thrombin -anti-thrombin antibody, and Rev-peptide -anti-Rev aptamer are presented. In order to improve the signal-to-noise ratio the use of reference sensors has been explored. The interaction of prostate specific antigen (PSA) to an anti-PSA antibody is shown to demonstrate the detection at concentrations as low as 10 nM.
Keywords :
biosensors; impedance biosensor system; prostate specific antigen; receptor ligand interactions; reference sensors; Biological interactions; Biosensors; Blood; Cancer detection; Electrodes; Frequency; Nanobioscience; Prostate cancer; Sensor systems; Surface impedance;
Conference_Titel :
Sensors, 2006. 5th IEEE Conference on
Conference_Location :
Daegu
Print_ISBN :
1-4244-0375-8
Electronic_ISBN :
1930-0395
DOI :
10.1109/ICSENS.2007.355768
