Title :
Variability of tissue optical properties in cancer patients receiving photodynamic therapy
Author :
Jacques, S.L. ; Bargo, P. ; Goodell, T. ; Sleven, R. ; Kovall, G. ; Blair, G.
Author_Institution :
Providence St. Vincent Med. Center, OR, USA
Abstract :
Photodynamic Therapy (PDT) uses light to activate photosensitive drug to yield oxidative injury to targeted tissues such as cancer. The ability of treatment light to penetrate a tissue and activate the drug that has accumulated in a target tissue depends on the tissue optical properties, especially the blood perfusion. An endoscopic spectroscopic probe was developed for monitoring esophageal and lung tissues and tested in patients in a pilot clinical study.
Keywords :
biological tissues; cancer; endoscopes; haemorheology; lung; oxidation; photodynamic therapy; probes; blood perfusion; cancer patients receiving photodynamic therapy; drug activation; endoscopic spectroscopic probe; esophageal tissues; lung tissues; photosensitizive drug activation; pilot clinical study; targeted tissues; tissue optical properties variability; Blood; Cancer; Drugs; Esophagus; Injuries; Lungs; Medical treatment; Patient monitoring; Probes; Spectroscopy;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1053283
