Optical sectioning wide-field microscopy for imaging oral cancer

Author

Abd-El-Barr, M.M. ; Hsu, E.R. ; Anslyn, E.V. ; Descour, M.R. ; Lotan, R. ; Gillenwate, A.M. ; Richards-Kortum, R.R.

Author_Institution

Dept. of Biomed. Eng., Univ. of Texas, Austin, TX, USA

Volume

3

fYear

2002

fDate

23-26 Oct. 2002

Firstpage

2306

Abstract

We describe the use of an optical sectioning wide-field microscope with an exogenous dye in order to improve the visualization of early oral cancer detection. We show positive results in imaging and optically sectioning turbid tissue phantoms stained with Acridine Orange, a non-specific fluorescent DNA dye. This optical technique, if coupled with appropriate contrast agents could improve both the visualization and specificity of epithelial cancer detection.

Keywords

DNA; biomedical optical imaging; cancer; dyes; fluorescence; optical microscopy; phantoms; tumours; turbidity; advanced stages; epithelial cancer detection; medical diagnostic imaging; nonspecific fluorescent DNA dye; optical sectioning wide-field microscopy; optically sectioning turbid tissue phantoms; oral cancer imaging; specificity; visualization; Biomedical optical imaging; Cancer detection; Gratings; Image resolution; Optical attenuators; Optical filters; Optical imaging; Optical microscopy; Optical scattering; Visualization;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1053295

Filename

1053295