Lithium Tantalate Surface Acoustic Wave Sensors for Bio-Analytical Applications

Author

Malavé, A. ; Schlecht, U. ; Gronewold, T.M.A. ; Perpeet, M. ; Tewes, M.

Author_Institution

Center of Adv. Eur. Studies & Res. (caesar), Bonn

fYear

2006

fDate

22-25 Oct. 2006

Firstpage

604

Lastpage

607

Abstract

A novel chip-based measurement system for marker-free detection of affinity and molecular interaction kinetics has been developed. Lithium tantalate (LiTaO₃) based Love-wave sensors are utilized as an alternative to quartz as substrate material in order to improve both the sensitivity and the limit-of-detection (LOD). Monitoring the coupling of thrombin to its antibody at low concentrations 1 nM and 10 nM showed phase changes of Deltaphi = 0.10deg and 0.35deg, respectively, for an active sensor area of 5.6 mm². We have found that the estimated detection limit for thrombin is on the order of 0.18 nM for our LiTaO₃ sensors.

Keywords

biosensors; lithium compounds; surface acoustic wave sensors; tantalum compounds; LiTaO₃; Love-wave sensors; bio-analytical applications; chip-based measurement system; limit-of-detection; lithium tantalate surface acoustic wave sensors; marker-free detection; molecular interaction kinetics; quartz; substrate material; thrombin coupling; Acoustic measurements; Acoustic sensors; Acoustic signal detection; Acoustic waves; Biological materials; Biosensors; Kinetic theory; Lithium compounds; Semiconductor device measurement; Surface acoustic waves;

fLanguage

English

Publisher

ieee

Conference_Titel

Sensors, 2006. 5th IEEE Conference on

Conference_Location

Daegu

ISSN

1930-0395

Print_ISBN

1-4244-0375-8

Electronic_ISBN

1930-0395

Type

conf

DOI

10.1109/ICSENS.2007.355540

Filename

4178692