A New Mathematical Model for Nanotoxicology Study

Author

Han, Yu ; Xu, Xiaoming ; Yin, Longping ; Liu, Shiyuan

Author_Institution

Dept. of Biomater., Nat. Eng. Res. Center for Nanotechnol., Shanghai, China

fYear

2009

fDate

11-13 June 2009

Firstpage

1

Lastpage

4

Abstract

In this paper, a dynamical system model has been proposed and a new approach for analyzing homeostasis and evaluating potential systemic toxicity in a living biological system has been developed for nanotoxicology study. Based on the model and approach, the toxicity of 30 nm-sized Fe₃O₄ nanoparticles was investigated and explained. Experiment results verify feasibility and effectiveness of the dynamical system we proposed. It also can be adapted to a wider range of applications such as general toxicology study, pharmacokinetics, efficacy and diagnosis.

Keywords

iron compounds; nanobiotechnology; nanoparticles; physiological models; toxicology; Fe₂O₄; Fe₃O₄ nanoparticles; homeostasis; nanotoxicology; pharmacokinetics; size 30 nm; toxicity; Aerodynamics; Aerospace materials; Animal structures; Biological system modeling; Biological systems; Mathematical model; Nanobioscience; Nanoparticles; Nanotechnology; Toxicology;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on

Conference_Location

Beijing

Print_ISBN

978-1-4244-2901-1

Electronic_ISBN

978-1-4244-2902-8

Type

conf

DOI

10.1109/ICBBE.2009.5162197

Filename

5162197