Title :
A New Mathematical Model for Nanotoxicology Study
Author :
Han, Yu ; Xu, Xiaoming ; Yin, Longping ; Liu, Shiyuan
Author_Institution :
Dept. of Biomater., Nat. Eng. Res. Center for Nanotechnol., Shanghai, China
Abstract :
In this paper, a dynamical system model has been proposed and a new approach for analyzing homeostasis and evaluating potential systemic toxicity in a living biological system has been developed for nanotoxicology study. Based on the model and approach, the toxicity of 30 nm-sized Fe3O4 nanoparticles was investigated and explained. Experiment results verify feasibility and effectiveness of the dynamical system we proposed. It also can be adapted to a wider range of applications such as general toxicology study, pharmacokinetics, efficacy and diagnosis.
Keywords :
iron compounds; nanobiotechnology; nanoparticles; physiological models; toxicology; Fe2O4; Fe3O4 nanoparticles; homeostasis; nanotoxicology; pharmacokinetics; size 30 nm; toxicity; Aerodynamics; Aerospace materials; Animal structures; Biological system modeling; Biological systems; Mathematical model; Nanobioscience; Nanoparticles; Nanotechnology; Toxicology;
Conference_Titel :
Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2901-1
Electronic_ISBN :
978-1-4244-2902-8
DOI :
10.1109/ICBBE.2009.5162197
