Title :
Microdialysis Glucose Sensor System Compared With Needle Type Glucose Sensor In Vivo During OGTT And Physical Exercise
Author :
Moon, B.U. ; Wientjes, K.J.C. ; Schoonen, A.J.M.
Author_Institution :
Groningen Univ., Groningen
Abstract :
The ´subcutaneous glucose monitoring system´ (SCGM) is based on microdialysis and allows continuous glucose monitoring in abdominal adipose tissue of diabetic patients up to 5 days. In the current in vivo study we compared the SCGM system with a commercially available needle type glucose sensor during an oral glucose tolerance test (OGTT) and during physical exercise. The SCGM had a good in vivo performance that was comparable to the needle type sensor. The inherent safe measuring technology of microdialysis and sensor stability of the SCGM makes it a likely candidate for online glucose measurement in diabetic patients. However, the overall system configuration is too bulky to wear comfortably and the measured values have a time lag of 35 min. The SCGM system will be the base for the future development of a miniaturized integrated microdialysis sensor system using lab-on-a-chip technology.
Keywords :
biosensors; computerised monitoring; patient monitoring; sugar; tolerance analysis; abdominal adipose tissue; diabetic patients; lab-on-a-chip technology; microdialysis; needle type glucose sensor; oral glucose tolerance test; sensor stability; subcutaneous glucose monitoring system; Abdomen; Diabetes; In vivo; Needles; Patient monitoring; Sensor systems; Stability; Sugar; System testing; Time measurement;
Conference_Titel :
Sensors, 2006. 5th IEEE Conference on
Conference_Location :
Daegu
Print_ISBN :
1-4244-0375-8
Electronic_ISBN :
1930-0395
DOI :
10.1109/ICSENS.2007.355793