Title :
Electrochemical Sensor for Determination of Metallothionein as Biomarker
Author :
Blastik, Ondrej ; Hubalek, Jaromir ; Adam, Vojtech ; Prasek, Jan ; Beklova, Miroslava ; Singer, Christoph ; Sures, Bernd ; Trnkova, Libuse ; Zehnalek, Josef ; Kizek, Rene
Author_Institution :
Mendel Univ. of Agric. & Forestry, Brno
Abstract :
Metallothionein (MT) belongs to group of intracellular, high molecular and cysteine-rich proteins. Thanks to its high affinity to heavy metals, the main function of this protein is maintaining homeostasis and detoxification of heavy metals. Thus, this protein is thought to be biomarker of heavy metal pollution. The adsorptive transfer stripping technique in connection with differential pulse voltammetry - Brdicka reaction has been utilized suggesting of sensor for determining of this biomarker.
Keywords :
electrochemical sensors; proteins; adsorptive transfer stripping technique; biomarker; cysteine-rich proteins; detoxification; differential pulse voltammetry; electrochemical sensor; heavy metal pollution; high molecular proteins; homeostasis; intracellular proteins; metallothionein; Biochemistry; Biomarkers; Biosensors; Cadmium; Chemical and biological sensors; Chemistry; Organisms; Pollution; Production; Proteins;
Conference_Titel :
Sensors, 2006. 5th IEEE Conference on
Conference_Location :
Daegu
Print_ISBN :
1-4244-0375-8
Electronic_ISBN :
1930-0395
DOI :
10.1109/ICSENS.2007.355839
