Title :
An Alternative Lidocaine Hydrochloride Liposomal Gel Formulation : Preparation, Percutaneous Permeation and Release Kinetics
Author :
Zhang, Xue-nong ; Gong, Jin-Hong ; Liu, Yang ; Tang, Li-Hua ; Xu, Xiao-jun
Author_Institution :
Coll. of Pharmacy, Soochow Univ., Suzhou, China
Abstract :
Liposomal hydrogel formulations of lidocaine hydrochloride(LDH)have been prepared and drug percutaneous permeation and release properties in vitro have been evaluated. An optimal hydrogel prescription with carbopol as base involved permeation enhancers as polyethylene glycol (PEG-400), Azone, poloxamer and propylene glycol was screened in vitro. Percutaneous permeation kinetic models of LDH in three formulations: liposome solution, conventional gel and liposomal gel were studied.
Keywords :
drugs; hydrogels; materials preparation; permeability; skin; Azone; LDH; PEG-400; carbopol; drug release kinetics; lidocaine hydrochloride liposomal gel formulation; optimal hydrogel prescription; percutaneous permeation kinetic models; poloxamer; polyethylene glycol; propylene glycol; transdermal therapeutic system; Anesthetic drugs; Biomembranes; Diseases; Drug delivery; In vitro; Kinetic theory; Lipidomics; Pharmaceuticals; Skin; Speech synthesis;
Conference_Titel :
Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2901-1
Electronic_ISBN :
978-1-4244-2902-8
DOI :
10.1109/ICBBE.2009.5162308
