Title :
Human neuroblastoma cultures for biorobotics
Author :
Ferrandez, J.M. ; Lorente, V. ; de Santos, D. ; Cuadra, J.M. ; de la Paz, F. ; Alvarez, J.R. ; Fernandez, Eduardo
Author_Institution :
Electron. & Comput. Technol. Dept., Univ. Politec. de Cartagena, Cartagena, Spain
fDate :
Aug. 30 2011-Sept. 3 2011
Abstract :
This paper introduces a new biorobotic system using human neuroblastoma cultures and centre of area learning for basic robotic guidance. Multielectrode Arrays Setups have been designed for direct culturing neural cells over silicon or glass substrates, providing the capability to stimulate and record simultaneously populations of neural cells. The main objective of this work will be to control a robot using this biological neuroprocessor and a new simple centre of area learning scheme. The final system could be applied for testing how chemicals affect the behaviour of the robot or to establish the basis for new hybrid optogenetic neuroprostheses based on stimulating optically genetic-modified neurons.
Keywords :
biomedical electrodes; cancer; cellular biophysics; medical robotics; neurophysiology; prosthetics; area learning scheme; biological neuroprocessor; biorobotics; glass substrates; human neuroblastoma cultures; hybrid optogenetic neuroprostheses; multielectrode arrays; neural cells; optically genetic-modified neurons; Data acquisition; Electrodes; Firing; Humans; Neurons; Robot kinematics; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Electrodes; Electromagnetic Phenomena; Electrophysiology; Humans; Microelectrodes; Models, Biological; Models, Genetic; Neuroblastoma; Neurons; Robotics; Software;
Conference_Titel :
Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-4121-1
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2011.6091645