Title :
Cluster sizes in interleaved silent steady state (ISSS) imaging
Author :
Akrofi, Kwaku ; Sutton, Bradley P. ; Ouyang, Cheng ; Husain, Fatima T.
Author_Institution :
Dept. of Speech & Hearing Sci., Univ. of Illinois at Urbana-Champaign (UIUC), Champaign, IL, USA
fDate :
Aug. 30 2011-Sept. 3 2011
Abstract :
The effect of increasing the number of scans in the “cluster” of an interleaved silent steady state (ISSS) fMRI imaging scheme from 1 to 2, and then to 3 was examined by a fixed-effects analysis of an auditory short-term memory task with four subjects. Compared to a cluster size of 1, a cluster of 2 scans improved sensitivity at detecting brain activity and statistical power, while a cluster of 3 scans further improved statistical power but seemed not to improve sensitivity beyond that achieved with a cluster of 2 scans. The findings reveal that cluster size is a vital parameter for an ISSS imaging scheme.
Keywords :
biomedical MRI; brain; statistical analysis; ISSS imaging scheme; auditory short-term memory task; brain activity; cluster size; interleaved silent steady state fMRI imaging scheme; statistical power; Auditory system; Delay; Finite impulse response filter; Imaging; Noise; Sensitivity; Steady-state; Adult; Algorithms; Auditory Pathways; Brain; Brain Mapping; Cluster Analysis; Data Interpretation, Statistical; Female; Humans; Magnetic Resonance Imaging; Male; Memory; Memory, Short-Term; Models, Statistical; Sensitivity and Specificity; Time Factors;
Conference_Titel :
Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-4121-1
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2011.6091770
