Title :
Effects of Estrogen Contamination on Human Cells: Modeling and Prediction Based on Michaelis-Menten Kinetics
Author :
Ibrahim, Fadi ; Huang, Biao ; Xing, James Z. ; Roa, Wilson ; Gabos, Stephan
Author_Institution :
Dept. of Chem. & Mater. Eng., Univ. of Alberta, Edmonton, AB, Canada
Abstract :
In this paper, a novel method is developed to predict the effect of estrogen on human living cells. This method is based on dynamic measurements coupled with a Michaelis-Menten type of mathematical modeling and parameter estimation procedure. The novelty of this method is the use of dynamic measurements generated by a real-time cell electronic sensor (RT-CES) system and the development of a mathematical model to predict the cell proliferation caused by estrogen stimulation.
Keywords :
biochemistry; biomedical electronics; biomedical measurement; cellular biophysics; parameter estimation; reaction kinetics theory; Michaelis-Menten kinetics; cell proliferation; dynamic measurement; estrogen contamination; human cell modeling; parameter estimation procedure; real-time cell electronic sensor; Cancer; Chemicals; Contamination; Endocrine system; Humans; Kinetic theory; Mathematical model; Pollution measurement; Predictive models; Water pollution;
Conference_Titel :
Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2901-1
Electronic_ISBN :
978-1-4244-2902-8
DOI :
10.1109/ICBBE.2009.5162739
