The effects of voluntary, involuntary, and forced exercises on motor recovery in a stroke rat model

Author

Ke, Zheng ; Yip, Shea-Ping ; Li, Le ; Zheng, Xiao-Xiang ; Tam, Wing-Kin ; Tong, Kai-Yu

Author_Institution

Dept. of Health Technol. & Inf., Hong Kong Polytech. Univ., Hong Kong, China

fYear

2011

fDate

Aug. 30 2011-Sept. 3 2011

Firstpage

8223

Lastpage

8226

Abstract

Stroke rehabilitation with different exercise paradigms has been investigated, but a comparison study on motor recovery after voluntary, involuntary, and forced exercises is limited. The current study used a rat brain ischemia model to investigate the effects of voluntary wheel running, involuntary muscle movement caused by functional electrical stimulation (FES), and forced treadmill exercise on motor recovery and brain BDNF changes. The results showed that voluntary exercise is the most effective intervention in upregulating the hippocampal BDNF level, and facilitating motor recovery after brain ischemia.

Keywords

biomechanics; brain models; diseases; neurophysiology; patient rehabilitation; exercise paradigms; forced exercises; functional electrical stimulation; hippocampal BDNF; involuntary exercises; involuntary muscle movement; motor recovery; rat brain ischemia model; stroke rat model; stroke rehabilitation; voluntary exercises; voluntary wheel running; Brain modeling; Educational institutions; Hippocampus; Muscles; Rats; Wheels; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Male; Motor Activity; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Recovery of Function; Stroke;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE

Conference_Location

Boston, MA

ISSN

1557-170X

Print_ISBN

978-1-4244-4121-1

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2011.6092028

Filename

6092028