Title :
Inter-Species Infection of Purified Eperythrozoon from Pig to Mice: Study on Haematological and Immunologic System
Author :
Yu, Fei ; Cui, Li ; Yuan, Cong-Li ; Liang, Ai-bin
Author_Institution :
Shanghai Key Lab. of Veterinary Biotechnol., Shanghai Jiaotong Univ., Shanghai, China
Abstract :
In this report, a new mouse model of Eperythrozoon infection was established to confirm inter-species infection, and the haematological and immunologic characteristics were studied. The infection was confirmed in mouse by traditional diagnosis combined with PCR and transmission electron microscope (EM) detection. Haematological data including total red cell count, erythrocrit, haemoglobin levels, and total white cell, lymphocyte and neutrophil counts were obtained. Lymphocyte transformation tests and rosette formation assays were performed to evaluate the immune function of infected mice. The results showed that total red cell count, erythrocrit and haemoglobin levels were remarkably lower in experimental group, and the rosette formation rate of red blood cell immune complexes were remarkably increased in experimental group.
Keywords :
biomedical imaging; blood; cellular biophysics; diseases; microorganisms; proteins; transmission electron microscopy; veterinary medicine; Eperythrozoon infection; PCR technique; erythrocrit; haematological characteristics; haemoglobin level; immune function evaluation; immunologic characteristics; infected mice; inter-species infection; lymphocyte count; lymphocyte transformation test; neutrophil count; red cell count; rosette formation assay; transmission electron microscope detection; Animals; Blood; Cells (biology); Diseases; Immune system; Mice; Microscopy; Organisms; Plasma temperature; Testing;
Conference_Titel :
Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2901-1
Electronic_ISBN :
978-1-4244-2902-8
DOI :
10.1109/ICBBE.2009.5162978
