Studies on biologically active schiff bases and their Chromium (III) complexes synthesized using microwave technique

The synthetic, spectroscopic and biological studies of some new chromium (III) complexes derived from biologically active nitrogen, sulphur/oxygen donor ligands 2-acetylthiophene thiosemicarbazone (L¹H) and 2-acetylthiophene semicarbazone (L²H) have been described. Both the ligands were prepared by the condensation of 2-acetylthiophene with thiosemicarbazide and semicarbazide hydrochloride (in presence of sodium acetate) in ethanol by using microwave as well as conventional methods. The main benefit of this approach is one of a timesaving nature. More recently, a number of other interesting effects have also been observed including the greener approach. The authenticity of the synthesized ligands and their complexes has been established on the basis of elemental analyses, molecular weight determinations, IR, EPR and UV spectral studies. Based these spectral studies an octahedral geometry has been assigned to these complexes. Studies were conducted to assess the comparative growth inhibiting potential of the synthesized complexes against the ligands for a variety of fungal and bacterial strains. The studies demonstrate that the ligands and complexes possess antimicrobial properties. Further, it was noted that the growth inhibiting potential of the complexes is greater than the parent ligands.