Micronucleus Kinetics Induced by Chromium Trioxide in Vicia Faba Root Tip Cells

Author

Zhang, Jie ; Zhang, Dan ; Yong, Liang ; Ling, Zhang

Author_Institution

Key Lab. of Subtropical Agric. & Environ., Huazhong Agric. Univ., Wuhan, China

fYear

2009

fDate

11-13 June 2009

Firstpage

1

Lastpage

3

Abstract

Aim of the present work was to establish the kinetics of micronucleus (MN) induction in Vicia faba root tip cells on the genotoxicity of chromium trioxide (CrO₃). The data indicate non-linear association between MN and exposure times in Vicia faba root tip cells. The maximal MN rate occurred at 24 h. The MN rates were increased in Vicia faba root tip cells from dose of 10^-8 to 10^-1 mol/L with treatment of upgraded degree of CrO₃, and regression equations can received by dualistic nonlinear regression analysis. In the context, increased frequency of micronucleated Vicia-celte is a useful biomarker of genotoxic effects that can reflect exposure to CrO₃ with clastogenic and aneugenic modes of action.

Keywords

agriculture; biotechnology; botany; cellular biophysics; chromium compounds; genetics; regression analysis; toxicology; CrO₃; Vicia faba; aneugenic modes; biomarker; clastogenic modes; dualistic nonlinear regression analysis; genotoxicity; micronucleus induction kinetics; nonlinear association; root tip cells; time 24 h; Agriculture; Cancer; Chromium; DNA; Frequency conversion; Kinetic theory; Lead compounds; Nonlinear equations; Regression analysis; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on

Conference_Location

Beijing

Print_ISBN

978-1-4244-2901-1

Electronic_ISBN

978-1-4244-2902-8

Type

conf

DOI

10.1109/ICBBE.2009.5163054

Filename

5163054