Title :
MMPs and TIMPs Expression and the Anterior Cruciate Ligament Repair
Author :
Xue, Ruyue ; Yang, Li ; Tang, Zhenyu ; Zhang, Jin ; Wang, Yequan ; Sung, KL Paul
Author_Institution :
111 project Lab. of Biomech. & Tissue Repair, Chongqing Univ., Chongqing, China
Abstract :
Human anterior cruciate ligament (ACL) has poor healing ability after injury. Inflammation and accumulation of matrix metalloproteinases (MMPs) in synovial fluids may be involved in the process. Tissue inhibitor metalloproteinases (TIMPs) may be independent of MMPs inhibition. A rat ACL rotating injury apparatus was designed to mimic ACL injury. ACL showed the higher MMP-l/TIMP-1 ratio after injury. Our recently findings demonstrated that MMPs expression and activities elevated significantly in the joint after ACL injury. This maybe one of the important reasons why an injured ACL cannot be repaired.
Keywords :
biochemistry; biological tissues; biomechanics; enzymes; molecular biophysics; ACL injury model; MMP expression; MMP inhibition; TIMP expression; anterior cruciate ligament repair; human anterior cruciate ligament; matrix metalloproteinase accumulation; matrix metalloproteinase inflammation; rat ACL rotating injury apparatus; synovial fluids; tissue inhibitor metalloproteinase; Animals; Biomedical engineering; Clamps; Educational institutions; Humans; Injuries; Joints; Knee; Ligaments; Rats;
Conference_Titel :
Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2901-1
Electronic_ISBN :
978-1-4244-2902-8
DOI :
10.1109/ICBBE.2009.5163062
