Preparation of Biopolymers Nanoparticles by Ultrasound Atomization

Microsphere particles have been introduced in a wide range of bio-medical applications, such as controlled drug delivery system and tissue repair materials. Microspheres can be produced in many ways including emulsion and stirring. These traditional methods have many restrictions such as large microspheres, production of air bubbles in the microspheres, uneven size and uneven morphology. All these can affect their applications. Ultrasound vibrations have frequencies higher than 20 kHz. Ultrasound can atomize medicines into tiny molecules. Through breathing, drugs can get into the respiratory tract for treatment. In order to improve the traditional preparation methods, this study suggests preparation using ultrasound atomization. Because the ultrasound transducer moves the micro-sized apertures very fast, materials can be atomized into particles, and the production rate is faster than traditional methods. The prepared alginate particles were analyzed by Dynamic Light Scattering System and the data expressed that alginate particles diameter distribution have two distinct peaks at 10 nm and 1000 nm. It was also expressed that while the viscosity of alginate increases, the diameter distribution of alginate particles decreases. This study´s results show that ultrasound atomization can prepare biopolymers particles as complete particles of the same size and morphology. Because these materials have excellent biocompatibility and are biodegradable, they can be applied to tissue engineering.