Title :
Preparation of Irisquinone Hydroxypropyl-beta-Cyclodextrin Inclusion Complex and Its Thermodynamic Stability
Author :
Zhang, Xue-nong ; Gong, Jin-Hong ; Tang, Li-Hua ; Zhang, Qiang
Author_Institution :
Coll. of Pharmacy, Soochow Univ., Suzhou, China
Abstract :
The inclusion complex formation of irisquinone with hydroxypropyl-beta-cyclodextrin(HP-beta-CD) and the physico- chemical properties were studied. Complex of host molecules with irisquinoe was studied by x-ray diffraction (XRD) and differential scanning calorimetry(DSC). The quantitative analysis with uv-vis indicated that HP-beta-CD could increase the solubility of irisquinone, where the best results was given with HP-beta-CD :irisquinone 2:1 molar ratio. The binding constants of inclusion complex formulation were obtained with relative Higuchi Principle and thermodynamics equation.
Keywords :
X-ray diffraction; biomedical materials; differential scanning calorimetry; organic compounds; pharmaceuticals; solubility; thermochemistry; ultraviolet spectra; visible spectra; DSC; HP-beta-CD; UV-VIS spectra; X-ray diffraction; XRD; differential scanning calorimetry; inclusion complex preparation; irisquinone hydroxypropyl-beta-cyclodextrin preparation; irisquinone solubility; physicochemical properties; relative Higuchi principle; thermodynamic equation; thermodynamic stability; Calorimetry; Cervical cancer; Chemicals; Degradation; Educational institutions; Liver neoplasms; Thermal stability; Thermodynamics; X-ray diffraction; X-ray scattering;
Conference_Titel :
Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2901-1
Electronic_ISBN :
978-1-4244-2902-8
DOI :
10.1109/ICBBE.2009.5163235
