Title :
ALGORITHM FOR IN VIVO CW FLUORESCENCE DIFFUSE OPTICAL TOMOGRAPHY TAKING INTO ACCOUNT OPTICAL HETEROGENEITIES OF BIOLOGICAL TISSUES AND THE SHAPE OF THE ANIMAL
Author :
Hervé, L. ; Koenig, A. ; Silva, A. Da ; Berger, M. ; Boutet, J. ; Peltié, P. ; Rizo, P. ; Dinten, J.M.
Author_Institution :
CEA-LETI, Grenoble
Abstract :
A fluorescence enhanced diffuse optical tomography algorithm taking into account the optical heterogeneities is presented. It is suitable for continuous wave acquisitions and naturally handles complex shaped object. Therefore, it allows in vivo studies of small animals injected with target-specific fluorescent probes without immersion fluid. A comparison with previous methods conducted on simulations is presented. A validation experiment performed on the same mouse at different stage of lung tumors growth shows the ability of the system to be used for biological studies
Keywords :
bio-optics; biological tissues; biomedical optical imaging; fluorescence; image reconstruction; lung; medical image processing; optical tomography; tumours; animal shape; biological tissues; complex shaped object; continuous wave acquisitions; continuous wave optical tomography; diffuse optical tomography; fluorescence; fluorescence reconstruction; in vivo optical tomography; lung tumors; mouse; optical heterogeneities; small animals; target-specific fluorescent probes; tumor growth; Animals; Biological system modeling; Biological tissues; Biomedical optical imaging; Fluorescence; In vivo; Mice; Probes; Shape; Tomography;
Conference_Titel :
Biomedical Imaging: From Nano to Macro, 2007. ISBI 2007. 4th IEEE International Symposium on
Conference_Location :
Arlington, VA
Print_ISBN :
1-4244-0672-2
Electronic_ISBN :
1-4244-0672-2
DOI :
10.1109/ISBI.2007.356976
