COMPARISON OF RADIATIVE TRANSPORT, MONTE CARLO, AND DIFFUSION FORWARD MODELS FOR SMALL ANIMAL OPTICAL TOMOGRAPHY

Author

Rasmussen, John C. ; Pan, Tianshu ; Joshia, Amit ; Wareing, Todd ; McGhee, John ; Sevick-Muraca, Eva M.

Author_Institution

Dept. of Radiol., Baylor Coll. of Med., Houston, TX

fYear

2007

fDate

12-15 April 2007

Firstpage

824

Lastpage

827

Abstract

Herein we present a comparison of Monte Carlo, radiative transport (RT), and diffusion based forward models for implementation into small animal optical tomography algorithm. The simulations show that the unique RT solver can accurately predict the time-dependent propagation of excitation and emission photons in diffuse as well as transport limited systems. Furthermore, the need for the accurate modeling of incident excitation illumination and the acceptance angle of the detector is demonstrated

Keywords

Monte Carlo methods; bio-optics; biodiffusion; biomedical optical imaging; drugs; optical tomography; patient treatment; Monte Carlo models; biodistribution; detector acceptance angle; diffusion forward models; drug candidates; emission photons; excitation photons; incident excitation illumination; radiative transport; small animal optical tomography; therapeutic efficacy; time-dependent propagation; transport limited systems; Animals; Biomedical optical imaging; Detectors; Equations; Fluorescence; Monte Carlo methods; Optical propagation; Optical scattering; Stimulated emission; Tomography;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Imaging: From Nano to Macro, 2007. ISBI 2007. 4th IEEE International Symposium on

Conference_Location

Arlington, VA

Print_ISBN

1-4244-0672-2

Electronic_ISBN

1-4244-0672-2

Type

conf

DOI

10.1109/ISBI.2007.356979

Filename

4193413