Title :
EMBRIOSS: ELECTROMAGNETIC BRAIN IMAGING BY OPTIMIZATION IN SPECTRAL SPACE
Author :
Vadakkumpadan, Fijoy ; Sun, Yinlong
Author_Institution :
Dept. of Comput. Sci., Purdue Univ., West Lafayette, IN
Abstract :
We propose a new method called electromagnetic brain imaging by optimization in spectral space (EMBRIOSS) for electromagnetic source imaging of the human brain. The method incorporates the physiological knowledge that electrical activities in the brain are spatially coherent and often sparse. For spatial coherency, we confine the solution to a subspace spanned by the low-frequency eigenvectors of a Laplacian of the cortical surface mesh. For sparseness, we apply a p-norm regularization with p < 2. The resulting nonlinear regularization problem is solved efficiently using half-quadratic programming. Through realistic simulations, we have compared our method with existing approaches. The results show that our method performs better
Keywords :
Laplace equations; bioelectric phenomena; biomedical imaging; brain models; eigenvalues and eigenfunctions; magnetoencephalography; mesh generation; EMBRIOSS; Laplacian eigenvectors; MEG source signal; brain activities; cortical surface mesh; electrical activities; electromagnetic brain imaging; electromagnetic source imaging; half-quadratic programming; head model; human brain; low-frequency eigenvectors; nonlinear regularization problem; optimization; p-norm regularization; sparseness; spatial coherency; spectral space; Biomedical imaging; Brain modeling; Electroencephalography; Gain measurement; Humans; Linear systems; Magnetic field measurement; Noise measurement; Sensor systems; Spatial coherence;
Conference_Titel :
Biomedical Imaging: From Nano to Macro, 2007. ISBI 2007. 4th IEEE International Symposium on
Conference_Location :
Arlington, VA
Print_ISBN :
1-4244-0672-2
Electronic_ISBN :
1-4244-0672-2
DOI :
10.1109/ISBI.2007.357029